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Angela Patti

Angela Patti graduated with honors in Organic Chemistry at the University of Catania discussing a thesis on the aminoacidic composition of melanosomes from Rana esculenta L. and since 1988 has worked as researcher at the Istituto di Chimica Biomolecolare (ICB) belonging to Consiglio Nazionale delle Ricerche, Italy.
She was a visiting researcher in the Keele University, Staffordshire UK (1997, COST D1/0002/94 fellowship) and in Ludwig Maximilians Universitat in Munich in the Prof. Paul Knochel laboratory (1999-2000) under the Short-term mobility and NATO-CNR Senior Fellowships Programmes.
Her first scientific activity was focused on the chemistry of natural compounds, then she turned to the use of lipases in organic solvents as selective biocatalysts for the preparation of several enantiopure compounds belonging to different structural classes. Since 2001 she has spent most part of research in the study of asymmetric reduction of chiral and prochiral diketones with different procedures (oxazaborolidine/borane promoted reduction and ruthenium-catalysed transfer hydrogenation) to give the corresponding optically active diols and in the development of new ferrocenyl-based ligands as efficient catalysts in asymmetric synthesis.
She currently works with several research groups applying her skills in the synthesis of chiral and achiral ferrocene compounds, biocatalytic reactions for the preparation of optically active compounds, chiral chromatography and NMR spectroscopy.
She is the author of a book entitled “Green approaches to asymmetric catalytic synthesis” (Springer Briefs in Green Chemistry for Sustainability, DOI: 10.1007 / 978-94-007-1454-0_1) whose 5 chapters have been the subject of> 3000 downloads from the date of publication (August 2011) to 2018
She has carried out teaching activities and participated in numerous national and international research projects, with the role of scientific coordinator and head of the training project “From natural compounds to nanostructured systems: applications and products for health” addressed to 8 scholarship holders (based on the ESF-OP funds Sicily 2007-2013 Notice Sicily Region 1 / 2012) and the training project “Chemical enabling technologies for health and environment” addressed to n. 9 scholarship holders (based on the ESF-OP funds Sicily 2014-2020 Notice Sicily Region 11/2017).
She was responsible for the scientific activities and the organization of activities related to the ICB participation at the 2016 Genoa Science Festival with the laboratory experience entitled “I recognize you, little molecule”. In this context she also made a video for children, entitled “Our friends enzymes”, which was shown during the activities with the public.
Member of the Scientific Council of the CNR Institute for the Study of Natural Substances of Food and Chemical-Pharmaceutical Interest from 1992 to 2001, he was a member of the Institute Council from 2009 to 2013.

SCIENTIFIC ACTIVITIES

Interests

The more recent research activity is mainly focused on the following topics:
• synthesis of ferrocenyl-conjugates of biologically active molecules and evaluation of their chemical, physical and biological properties
• development of biocatalytic method for the preparation of chiral drugs and biologically active compounds in enantioenriched form
• study of pharmaceutical formulations and characterization of the degradation profile of active ingredients

Recent publications

• Patti, A; Pedotti, S.; Mazzeo, G.; Longhi, G.; Abbate, S.; Paoloni, L.; Bloino, J.; Rampino, S.; Barone, V. Phys.Chem.Chem.Phys., 2019, 21, 9419-32
Ferrocenes with Simple Chiral Substituents: an In-Depth Theoretical and Experimental VCD and ECD Study

• Sanfilippo, C.; Paterna, A.; Biondi, D. M.; Patti A. Bioorganic Chem. 2019, 93, 103325
Lyophilized extracts from vegetable flours as valuable alternatives to purified oxygenases for the synthesis of oxylipins. DOI: 10.1016/j.bioorg.2019.103325

• Saita, M. G.; Aleo, D.; Melilli, B.; Patti, A. Int. J. Pharm. 2019, 566, 674-679
Effect of cyclodextrin additives on azithromycin in aqueous solution and insight into the stabilization mechanism by sulfobutyl ether-β-cyclodextrin

• Sanfilippo, C.; Paternò, A. A.; Patti, A. Mol. Catal. 2018, 449, 79-84
Resolution of racemic amines via lipase-catalyzed benzoylation: Chemoenzymatic synthesis of the pharmacologically active isomers of labetalol

• Saita, M. G.; Aleo, D.; Melilli, B.; Mangiafico, S.; Cro, M.; Sanfilippo, C.; Patti, A. J. Pharm. Biomed. Anal. 2018, 158, 47-53
pH-Dependent stability of azithromycin in aqueous solution and structure identification of two new degradation products

• Pedotti, S.; Ussia, M.; Patti, A.; Musso, N.; Barresi, V.; Condorelli, D. F. J. Organomet. Chem. 2017, 830, 56-61
Synthesis of the ferrocenyl analogue of clotrimazole drug

• Pedotti, S.; Patti A.; Dedola S.; Barberis A.;, Fabbri D.; Dettori, M. A.; Serra, P. A.; Delogu, G. Polyhedron, 2016, 117, 80-89
Synthesis of new ferrocenyl dehydrozingerone derivatives and their effects on viability of PC12 cells

• Sanfilippo, C.; Forni, A.; Patti, A.; RSC Advances 2016, 6, 49876-49882
Characterization of a conglomerate-forming derivative of (±)-milnacipran and its enantiomeric resolution by preferential crystallization

Keyword
Asymmetric synthesis, chirality, ferrocenes, green chemistry

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